Autophagy

Scientific explanation

recycles organelles and can support survival under nutrient or therapy stress. Context determines tumour-suppressive versus therapy-protective roles.

Cancers where relevant

Non-small-cell lung cancer Small-cell lung cancer EGFR-mutant NSCLC Pancreatic cancer Ovarian cancer Neuroendocrine prostate cancer Multiple myeloma Glioblastoma MGMT-methylated glioma Melanoma BRAF-driven melanoma

Compounds that intersect this pathway

Hydroxychloroquine

Lysosomotropic agent that raises endosomal/autophagosomal pH, impairing flux. Combination trials in oncology have been mixed; blockade is not equivalent to proven benefit.

Evidence in mapped cancers: Early Clinical · In Vivo · In Vitro

Azithromycin

Macrolide with immunomodulatory properties and experimental / observations. Not an anticancer indication.

This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.