Oncology pathway explorer
Hedgehog
Scientific explanation
Hedgehog–GLI signalling patterns development and can support basal-cell and some stromal/stem-like tumour programmes. Ligand-dependent stromal Hedgehog is distinct from mutation-driven ligand-independent activation.
Cancers where relevant
Compounds that intersect this pathway
Azole antifungal; off-target reports include Hedgehog-pathway antagonism and anti-angiogenic endothelial effects in experimental and early clinical settings. Not a licensed antineoplastic.
Evidence in mapped cancers: Early Clinical · In Vivo · In Vitro
Convergence partners
Other pathways that co-occur with Hedgehog on mapped adjunct records: Angiogenesis.
This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.