Hippo / YAP

Scientific explanation

Hippo signalling restrains YAP/TAZ transcriptional co-activators. NF2 loss, common in mesothelioma, derepresses YAP-driven growth programmes.

Cancers where relevant

Mesothelioma Pancreatic cancer

Compounds that intersect this pathway

This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.