Notch

Scientific explanation

Notch receptors undergo ligand-induced cleavage to NICD, altering lineage and stem/progenitor decisions. Context determines oncogenic versus tumour-suppressive roles.

Cancers where relevant

Small-cell lung cancer Neuroendocrine prostate cancer Acute lymphoblastic leukemia Neuroendocrine tumors

Compounds that intersect this pathway

This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.