One-carbon / methionine metabolism

Scientific explanation

Folate-methionine cycles supply nucleotides and methylation. Some tumours show methionine dependence and PHGDH or SHMT rewiring.

Cancers where relevant

Acute myeloid leukemia Multiple myeloma IDH-mutant glioma

Compounds that intersect this pathway

This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.