Wnt/β-catenin

Scientific explanation

Canonical Wnt signalling stabilizes β-catenin, driving TCF/LEF . APC loss is a classic colorectal initiating event; the pathway also contributes to stemness in several tissues.

Cancers where relevant

Colorectal cancer MSI-high colorectal cancer MSS colorectal cancer KRAS-mutant colorectal cancer BRAF-mutant colorectal cancer APC-driven colorectal cancer Gastric cancer Hepatocellular carcinoma Liver cancer Cholangiocarcinoma Endometrial cancer Prostate cancer Castration-resistant prostate cancer Sarcomas Bone cancers

Compounds that intersect this pathway

Niclosamide

uncoupler in cestodes; mammalian models report , Wnt/β-catenin and modulation. Those host-signalling findings are investigational/preclinical.

Evidence in mapped cancers: In Vitro · In Vivo · Mechanistically Plausible

Ivermectin

Glutamate-gated chloride channel in invertebrates. Reported mammalian effects on nuclear transport and signalling pathways come from experimental systems and do not constitute proven anticancer therapy.

Convergence partners

Other pathways that co-occur with Wnt/β-catenin on mapped adjunct records: JAK/STAT, mTOR.

This oncology atlas is educational. Pathway maps, adjunctive strategies, and compound listings describe mechanistic relevance. They do not establish clinical efficacy, do not recommend treatment, and are not a substitute for oncology care. Evidence tiers are not equivalent.